Mitochondrial Protein Adduct and Superoxide Generation are Prerequisites for Early Activation of c-Jun N-terminal Kinase within the Cytosol after an Acetaminophen Overdose in Mice

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States and formation of APAP-protein adducts, mitochondrial oxidant stress and activation of the mitogen activated protein (MAP) kinase c-jun N-terminal kinase (JNK) are critical for APAP-induced cell death....

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Pubblicato in:Toxicol Lett
Autori principali: Nguyen, Nga T., Du, Kuo, Akakpo, Jephte Y., Umbaugh, David S., Jaeschke, Hartmut, Ramachandran, Anup
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852579/
https://ncbi.nlm.nih.gov/pubmed/33290831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2020.12.005
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