ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer

Pancreatic ductal adenocarcinoma is a lethal disease characterized by late diagnosis, propensity for early metastasis and resistance to chemotherapy. Little is known about the mechanisms that drive innate therapeutic resistance in pancreatic cancer. The ataxia-telangiectasia group D-associated gene...

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Detalles Bibliográficos
Publicado en:Genes Dev
Main Authors: Purohit, Vinee, Wang, Lidong, Yang, Huibin, Li, Jiufeng, Ney, Gina M., Gumkowski, Erica R., Vaidya, Akash J., Wang, Annie, Bhardwaj, Amit, Zhao, Ende, Dolgalev, Igor, Zamperone, Andrea, Abel, Ethan V., Magliano, Marina Pasca Di, Crawford, Howard C., Diolaiti, Daniel, Papagiannakopoulos, Thales Y., Lyssiotis, Costas A., Simeone, Diane M.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2021
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849366/
https://ncbi.nlm.nih.gov/pubmed/33446568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.344184.120
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