ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer

Pancreatic ductal adenocarcinoma is a lethal disease characterized by late diagnosis, propensity for early metastasis and resistance to chemotherapy. Little is known about the mechanisms that drive innate therapeutic resistance in pancreatic cancer. The ataxia-telangiectasia group D-associated gene...

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Библиографические подробности
Опубликовано в: :Genes Dev
Главные авторы: Purohit, Vinee, Wang, Lidong, Yang, Huibin, Li, Jiufeng, Ney, Gina M., Gumkowski, Erica R., Vaidya, Akash J., Wang, Annie, Bhardwaj, Amit, Zhao, Ende, Dolgalev, Igor, Zamperone, Andrea, Abel, Ethan V., Magliano, Marina Pasca Di, Crawford, Howard C., Diolaiti, Daniel, Papagiannakopoulos, Thales Y., Lyssiotis, Costas A., Simeone, Diane M.
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2021
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849366/
https://ncbi.nlm.nih.gov/pubmed/33446568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.344184.120
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