ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis

Pancreatic adenocarcinoma (PDA) is an aggressive disease driven by oncogenic KRAS and characterized by late diagnosis and therapeutic resistance. Here we show that deletion of the ataxia-telangiectasia group D-complementing (Atdc) gene, whose human homolog is up-regulated in the majority of pancreat...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Wang, Lidong, Yang, Huibin, Zamperone, Andrea, Diolaiti, Daniel, Palmbos, Phillip L., Abel, Ethan V., Purohit, Vinee, Dolgalev, Igor, Rhim, Andrew D., Ljungman, Mats, Hadju, Christina H., Halbrook, Christopher J., Bar-Sagi, Dafna, di Magliano, Marina Pasca, Crawford, Howard C., Simeone, Diane M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546061/
https://ncbi.nlm.nih.gov/pubmed/31048544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.323303.118
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