ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer

Pancreatic ductal adenocarcinoma is a lethal disease characterized by late diagnosis, propensity for early metastasis and resistance to chemotherapy. Little is known about the mechanisms that drive innate therapeutic resistance in pancreatic cancer. The ataxia-telangiectasia group D-associated gene...

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Dades bibliogràfiques
Publicat a:Genes Dev
Autors principals: Purohit, Vinee, Wang, Lidong, Yang, Huibin, Li, Jiufeng, Ney, Gina M., Gumkowski, Erica R., Vaidya, Akash J., Wang, Annie, Bhardwaj, Amit, Zhao, Ende, Dolgalev, Igor, Zamperone, Andrea, Abel, Ethan V., Magliano, Marina Pasca Di, Crawford, Howard C., Diolaiti, Daniel, Papagiannakopoulos, Thales Y., Lyssiotis, Costas A., Simeone, Diane M.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2021
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849366/
https://ncbi.nlm.nih.gov/pubmed/33446568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.344184.120
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