ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer

Pancreatic ductal adenocarcinoma is a lethal disease characterized by late diagnosis, propensity for early metastasis and resistance to chemotherapy. Little is known about the mechanisms that drive innate therapeutic resistance in pancreatic cancer. The ataxia-telangiectasia group D-associated gene...

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Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Purohit, Vinee, Wang, Lidong, Yang, Huibin, Li, Jiufeng, Ney, Gina M., Gumkowski, Erica R., Vaidya, Akash J., Wang, Annie, Bhardwaj, Amit, Zhao, Ende, Dolgalev, Igor, Zamperone, Andrea, Abel, Ethan V., Magliano, Marina Pasca Di, Crawford, Howard C., Diolaiti, Daniel, Papagiannakopoulos, Thales Y., Lyssiotis, Costas A., Simeone, Diane M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849366/
https://ncbi.nlm.nih.gov/pubmed/33446568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.344184.120
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