Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

In mammalian cells, nutrients and growth factors signal through an array of upstream proteins to regulate the mTORC1 growth control pathway. Because the full complement of these proteins has not been systematically identified, we developed a FACS-based CRISPR-Cas9 genetic screening strategy to pinpo...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Condon, Kendall J., Orozco, Jose M., Adelmann, Charles H., Spinelli, Jessica B., van der Helm, Pim W., Roberts, Justin M., Kunchok, Tenzin, Sabatini, David M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848693/
https://ncbi.nlm.nih.gov/pubmed/33483422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022120118
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