Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

In mammalian cells, nutrients and growth factors signal through an array of upstream proteins to regulate the mTORC1 growth control pathway. Because the full complement of these proteins has not been systematically identified, we developed a FACS-based CRISPR-Cas9 genetic screening strategy to pinpo...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Condon, Kendall J., Orozco, Jose M., Adelmann, Charles H., Spinelli, Jessica B., van der Helm, Pim W., Roberts, Justin M., Kunchok, Tenzin, Sabatini, David M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2021
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848693/
https://ncbi.nlm.nih.gov/pubmed/33483422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022120118
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items