Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics

Meclofenamate is a nonsteroidal anti-inflammatory drug used in the treatment of mild-to-moderate pain yet poses a rare risk of hepatotoxicity through an unknown mechanism. Nonsteroidal anti-inflammatory drug (NSAID) bioactivation is a common molecular initiating event for hepatotoxicity. Thus, we hy...

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Udgivet i:Drug Metab Dispos
Main Authors: Schleiff, Mary Alexandra, Flynn, Noah R., Payakachat, Sasin, Schleiff, Benjamin Mark, Pinson, Anna O., Province, Dennis W., Swamidass, S. Joshua, Boysen, Gunnar, Miller, Grover P.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2021
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841419/
https://ncbi.nlm.nih.gov/pubmed/33239334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000254
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