Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics

Meclofenamate is a nonsteroidal anti-inflammatory drug used in the treatment of mild-to-moderate pain yet poses a rare risk of hepatotoxicity through an unknown mechanism. Nonsteroidal anti-inflammatory drug (NSAID) bioactivation is a common molecular initiating event for hepatotoxicity. Thus, we hy...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Drug Metab Dispos
Hlavní autoři: Schleiff, Mary Alexandra, Flynn, Noah R., Payakachat, Sasin, Schleiff, Benjamin Mark, Pinson, Anna O., Province, Dennis W., Swamidass, S. Joshua, Boysen, Gunnar, Miller, Grover P.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2021
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841419/
https://ncbi.nlm.nih.gov/pubmed/33239334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000254
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky