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Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam
Meloxicam is a thiazole-containing NSAID that was approved for marketing with favorable clinical outcomes despite being structurally similar to the hepatotoxic sudoxicam. Introduction of a single methyl group on the thiazole results in an overall lower toxic risk, yet the group’s impact on P450 isoz...
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| Udgivet i: | Toxicol Lett |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7807415/ https://ncbi.nlm.nih.gov/pubmed/33253783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2020.11.015 |
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