Lamisil (terbinafine) Toxicity: Determining pathways to bioactivation through computational and experimental approaches

Lamisil (terbinafine) may cause idiosyncratic liver toxicity through a proposed toxicological mechanism involving the reactive metabolite 6,6-dimethyl-2-hepten-4-ynal (TBF-A). TBF-A toxicological relevance remains unclear due to a lack of identification of pathways leading to and competing with TBF-...

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Udgivet i:Biochem Pharmacol
Main Authors: Barnette, Dustyn A., Davis, Mary A., Dang, Na L., Pidugu, Anirudh S., Hughes, Tyler, Joshua Swamidass, S., Boysen, Gunnar, Miller, Grover P.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188815/
https://ncbi.nlm.nih.gov/pubmed/30076845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.07.043
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