Wird geladen...

Computationally Assessing the Bioactivation of Drugs by N-Dealkylation

Cytochromes P450 (CYPs) oxidize alkylated amines commonly found in drugs and other biologically active molecules, cleaving them into an amine and an aldehyde. Metabolic studies usually neglect to report or investigate aldehydes, even though they can be toxic. It is assumed that they are efficiently...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chem Res Toxicol
Hauptverfasser: Le Dang, Na, Hughes, Tyler B., Miller, Grover P., Swamidass, S. Joshua
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871345/
https://ncbi.nlm.nih.gov/pubmed/29355304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00191
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!