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Site of Reactivity Models Predict Molecular Reactivity of Diverse Chemicals with Glutathione

Drug toxicity is often caused by electrophilic reactive metabolites that covalently bind to proteins. Consequently, the quantitative strength of a molecule’s reactivity with glutathione (GSH) is a frequently used indicator of its toxicity. Through cysteine, GSH (and proteins) scavenges reactive mole...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Hughes, Tyler B., Miller, Grover P., Swamidass, S. Joshua
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871349/
https://ncbi.nlm.nih.gov/pubmed/25742281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00017
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