CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches

Lamisil (terbinafine) is an effective, widely prescribed antifungal drug that causes rare idiosyncratic hepatotoxicity. The proposed toxic mechanism involves a reactive metabolite, 6,6-dimethyl-2-hepten-4-ynal (TBF-A), formed through three N-dealkylation pathways. We were the first to characterize t...

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Bibliografiske detaljer
Udgivet i:	Chem Res Toxicol
Main Authors:	Davis, Mary A., Barnette, Dustyn A., Flynn, Noah R., Pidugu, Anirudh S., Swamidass, S. Joshua, Boysen, Gunnar, Miller, Grover P.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2019
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6692898/ https://ncbi.nlm.nih.gov/pubmed/30925039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00006
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CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches

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