CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches

Lamisil (terbinafine) is an effective, widely prescribed antifungal drug that causes rare idiosyncratic hepatotoxicity. The proposed toxic mechanism involves a reactive metabolite, 6,6-dimethyl-2-hepten-4-ynal (TBF-A), formed through three N-dealkylation pathways. We were the first to characterize t...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Chem Res Toxicol
Asıl Yazarlar: Davis, Mary A., Barnette, Dustyn A., Flynn, Noah R., Pidugu, Anirudh S., Swamidass, S. Joshua, Boysen, Gunnar, Miller, Grover P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692898/
https://ncbi.nlm.nih.gov/pubmed/30925039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00006
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller