Comprehensive Kinetic and Modeling Analyses Revealed CYP2C9 and 3A4 Determine Terbinafine Metabolic Clearance and Bioactivation

Terbinafine N-dealkylation pathways result in formation of 6,6-dimethyl-2-hepten-4-ynal (TBF-A), a reactive allylic aldehyde, that may initiate idiosyncratic drug induced liver toxicity. Previously, we reported on the importance of CYP2C19 and 3A4 as major contributors to TBF-A formation. In this st...

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Udgivet i:Biochem Pharmacol
Main Authors: Barnette, Dustyn A., Davis, Mary A., Flynn, Noah, Pidugu, Anirudh S., Swamidass, S. Joshua, Miller, Grover P.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905088/
https://ncbi.nlm.nih.gov/pubmed/31605674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2019.113661
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