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Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers

Are the dimer structures of active Ras isoforms similar? This question is significant since Ras can activate its effectors as a monomer; however, as a dimer, it promotes Raf’s activation and MAPK (mitogen-activated protein kinase) cell signalling. In the present study, we model possible catalytic do...

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Podrobná bibliografie
Vydáno v:Biochem J
Hlavní autoři: Jang, Hyunbum, Muratcioglu, Serena, Gursoy, Attila, Keskin, Ozlem, Nussinov, Ruth
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7830773/
https://ncbi.nlm.nih.gov/pubmed/27057007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160031
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