Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E(2) Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes

The transition from β-cell compensation to β-cell failure is not well understood. Previous works by our group and others have demonstrated a role for Prostaglandin EP3 receptor (EP3), encoded by the Ptger3 gene, in the loss of functional β-cell mass in Type 2 diabetes (T2D). The primary endogenous E...

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Опубликовано в: :Metabolites
Главные авторы: Schaid, Michael D., Zhu, Yanlong, Richardson, Nicole E., Patibandla, Chinmai, Ong, Irene M., Fenske, Rachel J., Neuman, Joshua C., Guthery, Erin, Reuter, Austin, Sandhu, Harpreet K., Fuller, Miles H., Cox, Elizabeth D., Davis, Dawn B., Layden, Brian T., Brasier, Allan R., Lamming, Dudley W., Ge, Ying, Kimple, Michelle E.
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7830513/
https://ncbi.nlm.nih.gov/pubmed/33467110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo11010058
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