Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E(2) Signaling and Enhances Diabetic β-Cell Function

Prostaglandin E(2) (PGE(2)) is derived from arachidonic acid, whereas PGE(3) is derived from eicosapentaenoic acid (EPA) using the same downstream metabolic enzymes. Little is known about the impact of EPA and PGE(3) on β-cell function, particularly in the diabetic state. In this work, we determined...

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Vydáno v:Diabetes
Hlavní autoři: Neuman, Joshua C., Schaid, Michael D., Brill, Allison L., Fenske, Rachel J., Kibbe, Carly R., Fontaine, Danielle A., Sdao, Sophia M., Brar, Harpreet K., Connors, Kelsey M., Wienkes, Haley N., Eliceiri, Kevin W., Merrins, Matthew J., Davis, Dawn B., Kimple, Michelle E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2017
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440023/
https://ncbi.nlm.nih.gov/pubmed/28193789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1362
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