Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS‐1 (832/3) cell glucose‐stimulated insulin secretion

Chronic elevations in fatty acid metabolites termed prostaglandins can be found in circulation and in pancreatic islets from mice or humans with diabetes and have been suggested as contributing to the β‐cell dysfunction of the disease. Two‐series prostaglandins bind to a family of G‐protein‐coupled...

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Pubblicato in:Pharmacol Res Perspect
Autori principali: Sandhu, Harpreet K., Neuman, Joshua C., Schaid, Michael D., Davis, Sarah E., Connors, Kelsey M., Challa, Romith, Guthery, Erin, Fenske, Rachel J., Patibandla, Chinmai, Breyer, Richard M., Kimple, Michelle E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7947324/
https://ncbi.nlm.nih.gov/pubmed/33694300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.736
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