Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E(2) Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes

The transition from β-cell compensation to β-cell failure is not well understood. Previous works by our group and others have demonstrated a role for Prostaglandin EP3 receptor (EP3), encoded by the Ptger3 gene, in the loss of functional β-cell mass in Type 2 diabetes (T2D). The primary endogenous E...

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Vydáno v:Metabolites
Hlavní autoři: Schaid, Michael D., Zhu, Yanlong, Richardson, Nicole E., Patibandla, Chinmai, Ong, Irene M., Fenske, Rachel J., Neuman, Joshua C., Guthery, Erin, Reuter, Austin, Sandhu, Harpreet K., Fuller, Miles H., Cox, Elizabeth D., Davis, Dawn B., Layden, Brian T., Brasier, Allan R., Lamming, Dudley W., Ge, Ying, Kimple, Michelle E.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7830513/
https://ncbi.nlm.nih.gov/pubmed/33467110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo11010058
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