Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling

Genetic engineering of induced pluripotent stem cells (iPSCs) holds great promise for gene and cell therapy as well as drug discovery. However, there are potential concerns regarding the safety and control of gene expression using conventional vectors such as viruses and plasmids. Although human art...

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Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Kazuki, Yasuhiro, Uno, Narumi, Abe, Satoshi, Kajitani, Naoyo, Kazuki, Kanako, Yakura, Yuwna, Sawada, Chiaki, Takata, Shuta, Sugawara, Masaki, Nagashima, Yuichi, Okada, Akane, Hiratsuka, Masaharu, Osaki, Mitsuhiko, Ferrari, Giulia, Tedesco, Francesco Saverio, Nishikawa, Satoshi, Fukumoto, Ken, Takayanagi, Shin-ichiro, Kunisato, Atsushi, Kaneko, Shin, Oshimura, Mitsuo, Tomizuka, Kazuma
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819819/
https://ncbi.nlm.nih.gov/pubmed/33552683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.12.012
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