Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies

Infants with Down syndrome (DS) are at a high risk of developing transient abnormal myelopoiesis (TAM). A GATA1 mutation leading to the production of N-terminally truncated GATA1 (GATA1s) in early megakaryocyte/erythroid progenitors is linked to the onset of TAM and cooperated with the effect of tri...

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Autores principales: Kazuki, Yasuhiro, Yakura, Yuwna, Abe, Satoshi, Osaki, Mitsuhiko, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Honma, Kazuhisa, Suemori, Hirofumi, Yamazaki, Satoshi, Sakuma, Tetsushi, Toki, Tsutomu, Shimizu, Ritsuko, Nakauchi, Hiromitsu, Yamamoto, Takashi, Oshimura, Mitsuo
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145315/
https://ncbi.nlm.nih.gov/pubmed/25159877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06136
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