Shuttling of Peptide‐Drug Conjugates by G Protein‐Coupled Receptors Is Significantly Improved by Pulsed Application

G protein‐coupled receptors (GPCRs) can be used to shuttle peptide‐drug conjugates into cells. But, for efficient therapy, a high concentration of cargo needs to be delivered. To explore this, we studied the pharmacologically interesting neuropeptide Y(1) receptor (Y(1)R) in one recombinant and thre...

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Publicado en:ChemMedChem
Main Authors: Ziffert, Isabelle, Kaiser, Anette, Hoppenz, Paul, Mörl, Karin, Beck‐Sickinger, Annette G.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818256/
https://ncbi.nlm.nih.gov/pubmed/32700391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000490
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