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Unusually persistent Gα(i)-signaling of the neuropeptide Y(2) receptor depletes cellular G(i/o) pools and leads to a G(i)-refractory state
BACKGROUND: A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y(2) receptor (hY(2)R) undergoes ligand dependent activation and internalization into intracellular compartments, followed by recycling to...
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| Publicado no: | Cell Commun Signal |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7104545/ https://ncbi.nlm.nih.gov/pubmed/32223755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00537-6 |
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