Unusually persistent Gα(i)-signaling of the neuropeptide Y(2) receptor depletes cellular G(i/o) pools and leads to a G(i)-refractory state

BACKGROUND: A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y(2) receptor (hY(2)R) undergoes ligand dependent activation and internalization into intracellular compartments, followed by recycling to...

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Udgivet i:Cell Commun Signal
Main Authors: Ziffert, Isabelle, Kaiser, Anette, Babilon, Stefanie, Mörl, Karin, Beck-Sickinger, Annette G.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104545/
https://ncbi.nlm.nih.gov/pubmed/32223755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00537-6
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