Unusually persistent Gα(i)-signaling of the neuropeptide Y(2) receptor depletes cellular G(i/o) pools and leads to a G(i)-refractory state

BACKGROUND: A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y(2) receptor (hY(2)R) undergoes ligand dependent activation and internalization into intracellular compartments, followed by recycling to...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Commun Signal
Auteurs principaux: Ziffert, Isabelle, Kaiser, Anette, Babilon, Stefanie, Mörl, Karin, Beck-Sickinger, Annette G.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104545/
https://ncbi.nlm.nih.gov/pubmed/32223755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00537-6
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