Peptide Modifications Differentially Alter G Protein-Coupled Receptor Internalization and Signaling Bias()

Although G protein-coupled receptors (GPCRs) are targeted by more clinically used drugs than any other type of protein, their ligand development is particularly challenging. Humans have four neuropeptide Y receptors: hY(1)R and hY(5)R are orexigenic, while hY(2)R and hY(4)R are anorexigenic, and rep...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Mäde, Veronika, Babilon, Stefanie, Jolly, Navjeet, Wanka, Lizzy, Bellmann-Sickert, Kathrin, Diaz Gimenez, Luis E., Mörl, Karin, Cox, Helen M., Gurevich, Vsevolod V., Beck-Sickinger, Annette G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704863/
https://ncbi.nlm.nih.gov/pubmed/25065900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201403750
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