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Peptide Modifications Differentially Alter G Protein-Coupled Receptor Internalization and Signaling Bias()
Although G protein-coupled receptors (GPCRs) are targeted by more clinically used drugs than any other type of protein, their ligand development is particularly challenging. Humans have four neuropeptide Y receptors: hY(1)R and hY(5)R are orexigenic, while hY(2)R and hY(4)R are anorexigenic, and rep...
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| Veröffentlicht in: | Angew Chem Int Ed Engl |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4704863/ https://ncbi.nlm.nih.gov/pubmed/25065900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201403750 |
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