Position and Length of Fatty Acids Strongly Affect Receptor Selectivity Pattern of Human Pancreatic Polypeptide Analogues

Pancreatic polypeptide (PP) is a satiety-inducing gut hormone targeting predominantly the Y(4) receptor within the neuropeptide Y multiligand/multireceptor family. Palmitoylated PP-based ligands have already been reported to exert prolonged satiety-inducing effects in animal models. Here, we suggest...

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Veröffentlicht in:ChemMedChem
Hauptverfasser: Mäde, Veronika, Bellmann-Sickert, Kathrin, Kaiser, Anette, Meiler, Jens, Beck-Sickinger, Annette G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518309/
https://ncbi.nlm.nih.gov/pubmed/25156249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402235
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