Pancreatic Polypeptide Is Recognized by Two Hydrophobic Domains of the Human Y(4) Receptor Binding Pocket

Structural characterization of the human Y(4) receptor (hY(4)R) interaction with human pancreatic polypeptide (hPP) is crucial, not only for understanding its biological function but also for testing treatment strategies for obesity that target this interaction. Here, the interaction of receptor mut...

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Hauptverfasser: Pedragosa-Badia, Xavier, Sliwoski, Gregory R., Dong Nguyen, Elizabeth, Lindner, Diana, Stichel, Jan, Kaufmann, Kristian W., Meiler, Jens, Beck-Sickinger, Annette G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937655/
https://ncbi.nlm.nih.gov/pubmed/24375409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.502021
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