Pancreatic Polypeptide Is Recognized by Two Hydrophobic Domains of the Human Y(4) Receptor Binding Pocket

Structural characterization of the human Y(4) receptor (hY(4)R) interaction with human pancreatic polypeptide (hPP) is crucial, not only for understanding its biological function but also for testing treatment strategies for obesity that target this interaction. Here, the interaction of receptor mut...

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Главные авторы: Pedragosa-Badia, Xavier, Sliwoski, Gregory R., Dong Nguyen, Elizabeth, Lindner, Diana, Stichel, Jan, Kaufmann, Kristian W., Meiler, Jens, Beck-Sickinger, Annette G.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2014
Предметы:
Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937655/
https://ncbi.nlm.nih.gov/pubmed/24375409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.502021
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