Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci

To uncover novel significant association signals (p<5×10(−8)), genome-wide association studies (GWAS) requires increasingly larger sample sizes to overcome statistical correction for multiple testing. As an alternative, we aimed to identify associations among suggestive signals (5 × 10(−8)≤p<5...

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Publicado en:eLife
Autores principales: Hammond, Reza K, Pahl, Matthew C, Su, Chun, Cousminer, Diana L, Leonard, Michelle E, Lu, Sumei, Doege, Claudia A, Wagley, Yadav, Hodge, Kenyaita M, Lasconi, Chiara, Johnson, Matthew E, Pippin, James A, Hankenson, Kurt D, Leibel, Rudolph L, Chesi, Alessandra, Wells, Andrew D, Grant, Struan FA
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Computational and Systems Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815306/
https://ncbi.nlm.nih.gov/pubmed/33459256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62206
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