Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci

To uncover novel significant association signals (p<5×10(−8)), genome-wide association studies (GWAS) requires increasingly larger sample sizes to overcome statistical correction for multiple testing. As an alternative, we aimed to identify associations among suggestive signals (5 × 10(−8)≤p<5...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hammond, Reza K, Pahl, Matthew C, Su, Chun, Cousminer, Diana L, Leonard, Michelle E, Lu, Sumei, Doege, Claudia A, Wagley, Yadav, Hodge, Kenyaita M, Lasconi, Chiara, Johnson, Matthew E, Pippin, James A, Hankenson, Kurt D, Leibel, Rudolph L, Chesi, Alessandra, Wells, Andrew D, Grant, Struan FA
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Computational and Systems Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815306/
https://ncbi.nlm.nih.gov/pubmed/33459256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62206
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