Small-molecule inhibitors for the Prp8 intein as antifungal agents

Self-splicing proteins, called inteins, are present in many human pathogens, including the emerging fungal threats Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga), the causative agents of cryptococcosis. Inhibition of protein splicing in Cryptococcus sp. interferes with activity of the o...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Zhong, Tharappel, Anil Mathew, Xu, Jimin, Lang, Yuekun, Green, Cathleen M., Zhang, Jing, Lin, Qishan, Chaturvedi, Sudha, Zhou, Jia, Belfort, Marlene, Li, Hongmin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812778/
https://ncbi.nlm.nih.gov/pubmed/33397721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008815118
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