Small-molecule inhibitors for the Prp8 intein as antifungal agents

Self-splicing proteins, called inteins, are present in many human pathogens, including the emerging fungal threats Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga), the causative agents of cryptococcosis. Inhibition of protein splicing in Cryptococcus sp. interferes with activity of the o...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Li, Zhong, Tharappel, Anil Mathew, Xu, Jimin, Lang, Yuekun, Green, Cathleen M., Zhang, Jing, Lin, Qishan, Chaturvedi, Sudha, Zhou, Jia, Belfort, Marlene, Li, Hongmin
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812778/
https://ncbi.nlm.nih.gov/pubmed/33397721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008815118
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