Small-molecule inhibitors for the Prp8 intein as antifungal agents

Self-splicing proteins, called inteins, are present in many human pathogens, including the emerging fungal threats Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga), the causative agents of cryptococcosis. Inhibition of protein splicing in Cryptococcus sp. interferes with activity of the o...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Li, Zhong, Tharappel, Anil Mathew, Xu, Jimin, Lang, Yuekun, Green, Cathleen M., Zhang, Jing, Lin, Qishan, Chaturvedi, Sudha, Zhou, Jia, Belfort, Marlene, Li, Hongmin
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812778/
https://ncbi.nlm.nih.gov/pubmed/33397721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008815118
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