Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors

[Image: see text] Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that control a wide variety of cellular functions such as cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking. PI3Kγ plays a critical role in mediating leukocyte chemotaxis as well...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Bandarage, Upul K., Aronov, Alex M., Cao, Jingrong, Come, Jon H., Cottrell, Kevin M., Davies, Robert J., Giroux, Simon, Jacobs, Marc, Mahajan, Sudipta, Messersmith, David, Moody, Cameron S., Swett, Rebecca, Xu, Jinwang
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812679/
https://ncbi.nlm.nih.gov/pubmed/33488974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00573
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