Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors

[Image: see text] The successful application of immunotherapy in the treatment of cancer relies on effective engagement of immune cells in the tumor microenvironment. Phosphoinositide 3-kinase γ (PI3Kγ) is highly expressed in tumor-associated macrophages, and its expression levels are associated wit...

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מידע ביבליוגרפי
הוצא לאור ב:ACS Med Chem Lett
Main Authors: Miles, Dillon H., Yan, Xuelei, Thomas-Tran, Rhiannon, Fournier, Jeremy, Sharif, Ehesan U., Drew, Samuel L., Mata, Guillaume, Lawson, Kenneth V., Ginn, Elaine, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G., Meleza, Cesar, Chen, Ada, Pham, Amber T., Park, Timothy, Swinarski, Debbie, Banuelos, Jesus, Schindler, Ulrike, Walters, Matthew J., Walker, Nigel P., Zhao, Xiaoning, Young, Stephen W., Chen, Jie, Jin, Lixia, Leleti, Manmohan Reddy, Powers, Jay P., Jeffrey, Jenna L.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2020
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667872/
https://ncbi.nlm.nih.gov/pubmed/33214836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00387
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