Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors

[Image: see text] The successful application of immunotherapy in the treatment of cancer relies on effective engagement of immune cells in the tumor microenvironment. Phosphoinositide 3-kinase γ (PI3Kγ) is highly expressed in tumor-associated macrophages, and its expression levels are associated wit...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Miles, Dillon H., Yan, Xuelei, Thomas-Tran, Rhiannon, Fournier, Jeremy, Sharif, Ehesan U., Drew, Samuel L., Mata, Guillaume, Lawson, Kenneth V., Ginn, Elaine, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G., Meleza, Cesar, Chen, Ada, Pham, Amber T., Park, Timothy, Swinarski, Debbie, Banuelos, Jesus, Schindler, Ulrike, Walters, Matthew J., Walker, Nigel P., Zhao, Xiaoning, Young, Stephen W., Chen, Jie, Jin, Lixia, Leleti, Manmohan Reddy, Powers, Jay P., Jeffrey, Jenna L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667872/
https://ncbi.nlm.nih.gov/pubmed/33214836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00387
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