Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors

[Image: see text] The successful application of immunotherapy in the treatment of cancer relies on effective engagement of immune cells in the tumor microenvironment. Phosphoinositide 3-kinase γ (PI3Kγ) is highly expressed in tumor-associated macrophages, and its expression levels are associated wit...

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出版年:ACS Med Chem Lett
主要な著者: Miles, Dillon H., Yan, Xuelei, Thomas-Tran, Rhiannon, Fournier, Jeremy, Sharif, Ehesan U., Drew, Samuel L., Mata, Guillaume, Lawson, Kenneth V., Ginn, Elaine, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G., Meleza, Cesar, Chen, Ada, Pham, Amber T., Park, Timothy, Swinarski, Debbie, Banuelos, Jesus, Schindler, Ulrike, Walters, Matthew J., Walker, Nigel P., Zhao, Xiaoning, Young, Stephen W., Chen, Jie, Jin, Lixia, Leleti, Manmohan Reddy, Powers, Jay P., Jeffrey, Jenna L.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2020
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667872/
https://ncbi.nlm.nih.gov/pubmed/33214836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00387
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