Discovery of Potent, Selective Triazolothiadiazole-Containing c-Met Inhibitors

[Image: see text] Herein, we report a novel series of highly potent and selective triazolothiadiazole c-Met inhibitors. Starting with molecule 5, we have applied structure-based drug design principles to identify the triazolothiadiazole ring system. We successfully replaced the metabolically unstabl...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Tang, Qing, Aronov, Alex M., Deininger, David D., Giroux, Simon, Lauffer, David J., Li, Pan, Liang, Jianglin, McGinty, Kira, Ronkin, Steven, Swett, Rebecca, Waal, Nathan, Boucher, Diane, Ford, Pamella J., Moody, Cameron S.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201751/
https://ncbi.nlm.nih.gov/pubmed/34141080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00094
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker