Discovery of Potent, Selective Triazolothiadiazole-Containing c-Met Inhibitors

[Image: see text] Herein, we report a novel series of highly potent and selective triazolothiadiazole c-Met inhibitors. Starting with molecule 5, we have applied structure-based drug design principles to identify the triazolothiadiazole ring system. We successfully replaced the metabolically unstabl...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Tang, Qing, Aronov, Alex M., Deininger, David D., Giroux, Simon, Lauffer, David J., Li, Pan, Liang, Jianglin, McGinty, Kira, Ronkin, Steven, Swett, Rebecca, Waal, Nathan, Boucher, Diane, Ford, Pamella J., Moody, Cameron S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201751/
https://ncbi.nlm.nih.gov/pubmed/34141080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00094
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