Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors

[Image: see text] Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that control a wide variety of cellular functions such as cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking. PI3Kγ plays a critical role in mediating leukocyte chemotaxis as well...

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Publicat a:ACS Med Chem Lett
Autors principals: Bandarage, Upul K., Aronov, Alex M., Cao, Jingrong, Come, Jon H., Cottrell, Kevin M., Davies, Robert J., Giroux, Simon, Jacobs, Marc, Mahajan, Sudipta, Messersmith, David, Moody, Cameron S., Swett, Rebecca, Xu, Jinwang
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812679/
https://ncbi.nlm.nih.gov/pubmed/33488974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00573
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