HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow

Normal growth and development of lymphatic structures depends on mechanical forces created by accumulating interstitial fluid. However, prolonged exposure to pathologic mechanical stimuli generated by chronically elevated lymph flow results in lymphatic dysfunction. The mechanisms that transduce the...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Boehme, Jason T., Morris, Catherine J., Chiacchia, Samuel R., Gong, Wenhui, Wu, Katherine Y., Kameny, Rebecca J., Raff, Gary W., Fineman, Jeffrey R., Maltepe, Emin, Datar, Sanjeev A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809484/
https://ncbi.nlm.nih.gov/pubmed/33446832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80882-1
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