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HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow

Normal growth and development of lymphatic structures depends on mechanical forces created by accumulating interstitial fluid. However, prolonged exposure to pathologic mechanical stimuli generated by chronically elevated lymph flow results in lymphatic dysfunction. The mechanisms that transduce the...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Boehme, Jason T., Morris, Catherine J., Chiacchia, Samuel R., Gong, Wenhui, Wu, Katherine Y., Kameny, Rebecca J., Raff, Gary W., Fineman, Jeffrey R., Maltepe, Emin, Datar, Sanjeev A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809484/
https://ncbi.nlm.nih.gov/pubmed/33446832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80882-1
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