FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs

Focal adhesion kinase (FAK) localizes to focal adhesions and is overexpressed in many cancers. FAK can also translocate to the nucleus, where it binds to, and regulates, several transcription factors, including MBD2, p53 and IL-33, to control gene expression by unknown mechanisms. We have used ATAC-...

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Publicado no:Sci Rep
Main Authors: Griffith, Billie G. C., Upstill-Goddard, Rosanna, Brunton, Holly, Grimes, Graeme R., Biankin, Andrew V., Serrels, Bryan, Byron, Adam, Frame, Margaret C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794255/
https://ncbi.nlm.nih.gov/pubmed/33420223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80111-9
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