Using Chromatin Accessibility to Delineate Therapeutic Subtypes in Pancreatic Cancer Patient-Derived Cell Lines

di Brunton, Holly, Garner, Ian M., Bailey, Ulla-Maja, Upstill-Goddard, Rosie, Bailey, Peter J.
Pubblicato in STAR Protoc (2020)

Analysis of Human Syndromes with Disordered Chromatin Reveals the Impact of Heterochromatin on the Efficacy of ATM-Dependent G(2)/M Checkpoint Arrest

di Brunton, Holly, Goodarzi, Aaron A., Noon, Angela T., Shrikhande, Amruta, Hansen, R. Scott, Jeggo, Penny A., Shibata, Atsushi
Pubblicazione 2011

FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs

di Griffith, Billie G. C., Upstill-Goddard, Rosanna, Brunton, Holly, Grimes, Graeme R., Biankin, Andrew V., Serrels, Bryan, Byron, Adam, Frame, Margaret C.
Pubblicato in Sci Rep (2021)

Visualisation of γH2AX Foci Caused by Heavy Ion Particle Traversal; Distinction between Core Track versus Non-Track Damage

di Nakajima, Nakako Izumi, Brunton, Holly, Watanabe, Ritsuko, Shrikhande, Amruta, Hirayama, Ryoichi, Matsufuji, Naruhiro, Fujimori, Akira, Murakami, Takeshi, Okayasu, Ryuichi, Jeggo, Penny, Shibata, Atsushi
Pubblicazione 2013

The immune-microenvironment confers resistance to MAP kinase pathway inhibitors through macrophage-derived TNFα

di Smith, Michael P., Sanchez-Laorden, Berta, O’Brien, Kate, Brunton, Holly, Ferguson, Jennifer, Young, Helen, Dhomen, Nathalie, Flaherty, Keith T., Frederick, Dennie T., Cooper, Zachary A., Wargo, Jennifer A., Marais, Richard, Wellbrock, Claudia
Pubblicazione 2014

Formate induces a metabolic switch in nucleotide and energy metabolism

di Oizel, Kristell, Tait-Mulder, Jacqueline, Fernandez-de-Cossio-Diaz, Jorge, Pietzke, Matthias, Brunton, Holly, Lilla, Sergio, Dhayade, Sandeep, Athineos, Dimitri, Blanco, Giovanny Rodriguez, Sumpton, David, Mackay, Gillian M., Blyth, Karen, Zanivan, Sara R., Meiser, Johannes, Vazquez, Alexei
Pubblicato in Cell Death Dis (2020)

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy

di Smith, Michael P., Brunton, Holly, Rowling, Emily J., Ferguson, Jennifer, Arozarena, Imanol, Miskolczi, Zsofia, Lee, Jessica L., Girotti, Maria R., Marais, Richard, Levesque, Mitchell P., Dummer, Reinhard, Frederick, Dennie T., Flaherty, Keith T., Cooper, Zachary A., Wargo, Jennifer A., Wellbrock, Claudia
Pubblicato in Cancer Cell (2016)

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

di Smith, Michael P, Rowling, Emily J, Miskolczi, Zsofia, Ferguson, Jennifer, Spoerri, Loredana, Haass, Nikolas K, Sloss, Olivia, McEntegart, Sophie, Arozarena, Imanol, von Kriegsheim, Alex, Rodriguez, Javier, Brunton, Holly, Kmarashev, Jivko, Levesque, Mitchell P, Dummer, Reinhard, Frederick, Dennie T, Andrews, Miles C, Cooper, Zachary A, Flaherty, Keith T, Wargo, Jennifer A, Wellbrock, Claudia
Pubblicato in EMBO Mol Med (2017)

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

di Dreyer, Stephan B., Upstill-Goddard, Rosie, Paulus-Hock, Viola, Paris, Clara, Lampraki, Eirini-Maria, Dray, Eloise, Serrels, Bryan, Caligiuri, Giuseppina, Rebus, Selma, Plenker, Dennis, Galluzzo, Zachary, Brunton, Holly, Cunningham, Richard, Tesson, Mathias, Nourse, Craig, Bailey, Ulla-Maja, Jones, Marc, Moran-Jones, Kim, Wright, Derek W., Duthie, Fraser, Oien, Karin, Evers, Lisa, McKay, Colin J., McGregor, Grant A., Gulati, Aditi, Brough, Rachel, Bajrami, Ilirjana, Pettitt, Stephan, Dziubinski, Michele L., Candido, Juliana, Balkwill, Frances, Barry, Simon T., Grützmann, Robert, Rahib, Lola, Johns, Amber, Pajic, Marina, Froeling, Fieke E.M., Beer, Phillip, Musgrove, Elizabeth A., Petersen, Gloria M., Ashworth, Alan, Frame, Margaret C., Crawford, Howard C., Simeone, Diane M., Lord, Chris, Mukhopadhyay, Debabrata, Pilarsky, Christian, Tuveson, David A., Cooke, Susanna L., Jamieson, Nigel B., Morton, Jennifer P., Sansom, Owen J., Bailey, Peter J., Biankin, Andrew V., Chang, David K.
Pubblicato in Gastroenterology (2021)