The immune-microenvironment confers resistance to MAP kinase pathway inhibitors through macrophage-derived TNFα

Recently the rationale for combining targeted therapy with immunotherapy has come to light, but our understanding of the immune response during MAPK pathway inhibitor treatment is limited. We discovered that the immune-microenvironment can act as source of resistance to MAPK pathway-targeted therapy...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Smith, Michael P., Sanchez-Laorden, Berta, O’Brien, Kate, Brunton, Holly, Ferguson, Jennifer, Young, Helen, Dhomen, Nathalie, Flaherty, Keith T., Frederick, Dennie T., Cooper, Zachary A., Wargo, Jennifer A., Marais, Richard, Wellbrock, Claudia
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2014
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184867/
https://ncbi.nlm.nih.gov/pubmed/25256614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-1007
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