The immune-microenvironment confers resistance to MAP kinase pathway inhibitors through macrophage-derived TNFα

Recently the rationale for combining targeted therapy with immunotherapy has come to light, but our understanding of the immune response during MAPK pathway inhibitor treatment is limited. We discovered that the immune-microenvironment can act as source of resistance to MAPK pathway-targeted therapy...

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Bibliografiske detaljer
Main Authors: Smith, Michael P., Sanchez-Laorden, Berta, O’Brien, Kate, Brunton, Holly, Ferguson, Jennifer, Young, Helen, Dhomen, Nathalie, Flaherty, Keith T., Frederick, Dennie T., Cooper, Zachary A., Wargo, Jennifer A., Marais, Richard, Wellbrock, Claudia
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184867/
https://ncbi.nlm.nih.gov/pubmed/25256614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-1007
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