The immune-microenvironment confers resistance to MAP kinase pathway inhibitors through macrophage-derived TNFα

Recently the rationale for combining targeted therapy with immunotherapy has come to light, but our understanding of the immune response during MAPK pathway inhibitor treatment is limited. We discovered that the immune-microenvironment can act as source of resistance to MAPK pathway-targeted therapy...

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Detalhes bibliográficos
Main Authors: Smith, Michael P., Sanchez-Laorden, Berta, O’Brien, Kate, Brunton, Holly, Ferguson, Jennifer, Young, Helen, Dhomen, Nathalie, Flaherty, Keith T., Frederick, Dennie T., Cooper, Zachary A., Wargo, Jennifer A., Marais, Richard, Wellbrock, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184867/
https://ncbi.nlm.nih.gov/pubmed/25256614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-1007
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