Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3(+) Regulatory T Cells via a miR-342-Dependent Mechanism

Glucocorticoids (GC) are the mainstay treatment option for inflammatory conditions. Despite the broad usage of GC, the mechanisms by which GC exerts its effects remain elusive. Here, utilizing murine autoimmune and allergic inflammation models, we report that Foxp3(+) regulatory T (Treg) cells are i...

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Veröffentlicht in:Immunity
Hauptverfasser: Kim, Dongkyun, Nguyen, Quang Tam, Lee, Juyeun, Lee, Sung Hwan, Janocha, Allison, Kim, Sohee, Le, Hongnga T., Dvorina, Nina, Weiss, Kelly, Cameron, Mark J., Asosingh, Kewal, Erzurum, Serpil C., Baldwin, William M., Lee, Ju-Seog, Min, Booki
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793548/
https://ncbi.nlm.nih.gov/pubmed/32707034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.07.002
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