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Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice

Vascular dysregulation and cholinergic basal forebrain degeneration are both early pathological events in the development of Alzheimer’s disease (AD). Acetylcholine contributes to localised arterial dilatation and increased cerebral blood flow (CBF) during neurovascular coupling via activation of en...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Nizari, Shereen, Wells, Jack A., Carare, Roxana O., Romero, Ignacio A., Hawkes, Cheryl A.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791879/
https://ncbi.nlm.nih.gov/pubmed/33413694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01108-z
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